Fanxin Long, PhDSince the early days of his scientific training, Dr. Long has been interested in understanding how the mammalian skeleton is formed and maintained in a functional state throughout life. Many of his studies have centered around key developmental pathways such as Hedgehog, Wnt and Notch signaling in bone development and homeostasis. Through mouse genetic studies, his group has defined specific functions of the developmental signals in bone cell differentiation. Their biochemical studies have led to the discovery that developmental signals reprogram cellular metabolism to change cell fate. The lab currently tests the hypothesis that dysregulation of glucose metabolism is a root cause for skeletal disorders associated with diabetes and aging. Dr. Long served on the program committee of the American Society of Bone and Mineral Research annual meeting in 2015, and was Chair of the Gordon Conference for Bones and Teeth in 2018. Prior to his current position, Dr. Long served as Professor of Medicine, Developmental Biology and Orthopedic Surgery at Washington University in St. Louis School of Medicine.