Fanxin Long, PhDSince the early days of his scientific training, Dr. Long has been interested in understanding how the mammalian skeleton is formed and maintained in a functional state throughout life. Many of his studies have centered around key developmental pathways such as Hedgehog, Wnt and Notch signaling in bone development and homeostasis. Through mouse genetic studies, his group has defined specific functions of the developmental signals in bone cell differentiation. Their biochemical studies have led to the discovery that developmental signals reprogram cellular metabolism to change cell fate. The lab currently tests the hypothesis that dysregulation of glucose metabolism is a root cause for skeletal disorders associated with diabetes and aging. Dr. Long served on the program committee of the American Society of Bone and Mineral Research annual meeting in 2015, and was Chair of the Gordon Conference for Bones and Teeth in 2018. Prior to his current position, Dr. Long served as Professor of Medicine, Developmental Biology and Orthopedic Surgery at Washington University in St. Louis School of Medicine.


Publications:

  • Lee SY and Long F. Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation. J Clin Invest. 2018 Oct 4. pii: 96221. doi: 10.1172/JCI96221. [Epub ahead of print]
  • Shi Y, He G, Lee WC, McKenzie JA, Silva MJ and Long F. Gli1 identifies osteogenic progenitors for bone formation and fracture repair. Nat. Comm. 2017; 8(1): 2043.
  • Emel Esen, Jianquan Chen, Courtney M. Karner, Adewole L. Okunade, Bruce W. Patterson, Fanxin Long (2013). WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab 17, 745-55. PMCID:PMC3653292.
  • Wu X, Tu X, Joeng KS, Hilton MJ, Williams DA, Long F. Rac1 activation controls nuclear localization of ß-catenin during canonical Wnt signaling. Cell 2008: 133: 340-353. PMCID: PMC2390926
  • Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 2008: 14: 306-314. PMCID: PMC2740725