Dr. Koyama’s biomedical research focuses on morphogenetic mechanisms that control limb and craniofacial skeletal formation and organization. He is interested in how these mechanisms could be used to stimulate tissue regeneration, and how changes in these mechanisms may cause congenital conditions such as hereditary multiple exostoses (HME) syndrome.
Terminal degrees: PhD, DDS
Publications:
- T. Nakamura T, L. Jimenez-Rojo, E. Koyama E, M. Pacifici, S. de Vega, M. Iwamoto, S. Fukumoto, F. Unda, Y. Yamada (2016). Epiprofin regulates enamel formation and tooth morphogenesis by controlling epithelial-mesenchymal interactions during tooth development. J Bone Miner Res. PMID:27787957
- TE. Bechtold, C. Saunders, RS. Decker, Um. HB, N. Cottingham, I. Salhab, N. Kurio, PC. Billings, M. Pacifici, HD. Nah, E. Koyama (2016). Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling. Matrix Biol. 52-54:339-54. PMID: 26945615
- TE. Bechtold, C. Saunders, C. Mundy, Um. HB, RS. Decker, I. Salhab, N. Kurio, PC. Billings, M. Pacifici, HD. Nah, E. Koyama (2016). Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4-null TMJ Discs. J Dent Res. 95(3):292-301. PMID: 26534931
- RS. Decker, E. Koyama, M. Pacifici (2015). Articular Cartilage: Structural and Developmental Intricacies and Questions. Curr Osteoporos Rep. PMID: 26408155
- C. Mundy, A. Bello, F. Sgariglia, E. Koyama, M Pacifici (2015). HhAntag, a Hedgehog Signaling Antagonist, Suppresses Chondrogenesis and Modulates Canonical and Non-Canonical BMP Signaling. J Cell Physiol. PMID: 26363135
- J. Huegel, M. Enomoto-Iwamoto, F. Sgariglia, E. Koyama, M. Pacifici. (2015). Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses. Am J Pathol. Jun;185(6):1676-85. PMID: 25863260
- T. Shimo, E. Koyama, N. Kurio, K. Matsumoto, T. Okui, S. Ibaragi, N. Yoshioka, A. Sasaki (2015). Expression and roles of CCN2 in dental epithelial cells. In Vivo. 29(2):189-95. PMID: 25792645
- RS. Decker, E. Koyama, M. Enomoto-Iwamoto, P. Maye, D. Rowe, S. Zhu, PG. Schultz, M. Pacifici. (2014). Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin. Dev Biol.15;395(2):255-67. PMID: 25238962
- RS. Decker, E. Koyama, M. Pacifici. (2014) Genesis and morphogenesis of limb synovial joints and articular cartilage. Matrix Biol. 2014 Oct;39:5-10. PMID: 25172830
- N. Chernets, J. Zhang, MJ. Steinbeck, DS. Kurpad, E. Koyama, G. Friedman, TA. Freeman. (2014). Nonthermal Atmospheric Pressure Plasma Enhances Mouse Limb Bud Survival, Growth, and Elongation. Nonthermal Atmospheric Pressure Plasma Enhances Mouse Limb Bud Survival, Growth, and Elongation. Tissue Eng. Part A. PMID: 25102046
- E. Koyama, C. Saunders, I. Salhab , RS. Decker, I. Chen, Um H, M. Pacifici, HD. Nah. (2014). Lubricin is Required for the Structural Integrity and Post-natal Maintenance of TMJ. J Dent Res. 2014 May 16;93(7):663-670. PMID: 24834922
- Y. Ishizuka, Y. Shibukawa, M. Nagayama, R. Decker, T. Kinumatsu, A. Saito, M. Pacifici, E. Koyama. (2014). TMJ degeneration in SAMP8 mice is accompanied by deranged Ihh signaling. J Dent Res. 93(3):281-7. PMID: 24453178
